On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and OmicronArticle Published on 2022-12-012023-07-10 Journal: Journal of autoimmunity [Category] COVID19(2023년), [키워드] Delta variants Omicron variants SARS-CoV-2. [DOI] 10.1016/j.jaut.2022.102952 PMC 바로가기
RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variantSARS-CoV-2 Delta 변이체에서 R203M 돌연변이의 신속한 검출을 위한 RT-LAMP 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy amplification analyses appear AUC clinical samples conserved COVID-19 COVID-19 vaccines Delta delta variant Delta variants detect determined by Diagnosis discrepancy dominant Efficiency facilitate genotyping infected individuals Mutation N gene positive sample Primers quantification quarantine R203M mutation Rapid rapid diagnosis. RT-LAMP RT-qPCR SARS-CoV-2 sensitivity sequence Sequencing sets of primer sets of primers specificity specimen Surveillance threshold variant variants [DOI] 10.1080/22221751.2022.2054368 PMC 바로가기 [Article Type] Article
Covid-19 vaccination programme effectiveness against SARS-CoV-2 related infections, hospital admissions and deaths in the Apulia region of Italy: a one-year retrospective cohort studyArticle Published on 2022-11-032022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Ad26.COV2.S vaccine Alpha Apulia calculate ChAdOx1-S Cohort combined use conducted COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccination programme Cox regression model death deaths Delta variants dominant Effect Effectiveness Effects Electronic health record eligible estimate hazard ratio Hospital admission hospitalisation infections Italy mRNA-1273 of BNT162b2 Older outcome positive Protective reduced retrospective cohort study SARS-CoV-2 SARS-CoV-2 infections study period subject vaccination Vaccine variant variants waned were used yielding [DOI] 10.1038/s41598-022-23235-4 PMC 바로가기
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in PennsylvaniaArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha analyzed animal reservoir bat coronavirus coronavirus COVID-19 epidemic creating deer Delta Delta variants Epidemics example future infection genomic data help Host Human humans identify independent Infection information Lineage mammals management Multiple nasal swab North America observation occur Odocoileus Odocoileus virginianus positive replicate reported reservoir RT-qPCR SARS-CoV-2 SARS-CoV-2 pandemic significantly spike gene susceptible trajectory Transmission transmissions variant vertebrates white-tail deer white-tailed deer whole genome sequence zoonosis zoonosis. [DOI] 10.1128/mbio.02101-22 PMC 바로가기
Genomic diversity of SARS-CoV-2 in Pakistan during the fourth wave of pandemic전염병의 네 번째 물결 동안 파키스탄에서 SARS-CoV-2의 게놈 다양성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha B.1.617.2 Beta variant characteristic circulating circulation conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D950N delta variant Delta variants exhibited followed by G142D genomic Genomic surveillance Germany globe highlight Illumina isolate isolates Karachi L452R lineages P681R Pakistan pandemic Patient Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus Singapore spike mutation T19R T478K United Kingdom V483A variant variants variants of concern variants of concern. whole-genome sequencing [DOI] 10.1002/jmv.27957 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects side effects. significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
Receptor binding domain proteins of SARS-CoV-2 variants produced in Nicotiana benthamiana elicit neutralizing antibodies against variants of concernNicotiana benthamiana에서 생산된 SARS-CoV-2 변이체의 수용체 결합 도메인 단백질은 우려되는 변이체에 대한 중화 항체를 유도합니다Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (alpha Alpha Beta binding domain booster vaccination Booster vaccine cloned COVID-19 cross-reactive Day Delta Delta variants dose Effective vaccines elicit Epsilon evaluated expression vector Fc fragment fragment of Gamma gene encoding health problem human IgG1 immune response immunized immunogenicity induce intramuscularly mutant Mutation Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses Nicotiana benthamiana plant-produced recombinant protein produced Protein public health RBD RBD-Fc RBD-Fc fusion protein Receptor-binding domain Recombinant protein required respiratory SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome significantly Spread subunit Subunit vaccine tested the receptor-binding domain the vaccine the vaccines transient expression Vaccine variant variant vaccine. variants variants of concern VOCs Wuhan [DOI] 10.1002/jmv.27881 PMC 바로가기 [Article Type] Article
Fourth BNT162b2 vaccination neutralization of omicron infection after heart transplantationArticle Published on 2022-09-012022-11-15 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] Anti-RBD antibody anti-RBD IgG antibody Antibody Response BNT162b2 BNT162b2 vaccine cellular immunity changes in Delta variants demonstrated detectable domain dose Efficacy Efficiency elicit fourth dose group Heart transplantation high-risk population IgG immune responses Immunological response IMPROVE Infection investigated long-lasting majority neutralization neutralizing antibody neutralizing responses omicron Omicron variant preventive measure recipients vaccination Vaccination strategy variant variants of concern variants of concern. wild-type virus [DOI] 10.1016/j.healun.2022.04.014 PMC 바로가기
Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine RecipientsBNT162b2 또는 CoronaVac 백신 수혜자의 혈청에 의한 중증 급성 호흡기 증후군 코로나바이러스 2 오미크론 변이체의 중화Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Beta Beta variant beta variants BNT162b2 CoronaVac coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta variants detectable Effectiveness elicited evade genome sequence geometric geometric mean GISAID database GMT GMTs Health Organization isolate Lineage Live virus microneutralization Mutation Nanopore nanopore sequencing neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer no significant difference not affect of BNT162b2 omicron Omicron variant Patient recipient recipients respiratory risk Risk assessment SARS-CoV-2 Sequencing sera severe acute respiratory syndrome Coronavirus significant difference significantly lower spike mutation strain Strains susceptibility TMPRSS2 Vaccine Vaccines variant Variant of concern. VeroE6 cells virus was determined whole genome sequence World Health Organization [DOI] 10.1093/cid/ciab1041 PMC 바로가기 [Article Type] Article
BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19COVID-19에 대한 이종 또는 동종 ChAdOx1nCoV-19/BNT162b2 백신 접종 후 6개월 후 BNT162b2로 강화된 면역 반응Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] Alpha anti-Spike IgG approach B.1.1.529 Beta BNT BNT162b2 both groups CD4 CD8 Cell ChAd choice compensated delta variant Delta variants Effect followed by Frequency Gamma Heterologous homologous immune response immune responses Immunity in both groups increase in moderate mRNA vaccine Neutralizing activity Neutralizing antibody response neutralizing antibody responses omicron protective immunity repeated reported SARS-CoV-2 second vaccination subsequent T cell vaccinated individual vaccinated individuals vaccination vaccination against COVID-19 Vaccine variant virus [DOI] 10.1038/s41467-022-32527-2 PMC 바로가기 [Article Type] Article